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As its name suggests, IGF-1 is structurally similar to insulin and is capable of binding to the insulin receptor (I-R), albeit with a lower affinity than that towards IGF-1R

Moreover, it promoted mitophagy and mitochondrial fission/fusion homeostasis, increased SOD2 expression, downregulated ROS production, inhibited myocardial cell apoptosis and OS, and prevented MI injury in aging mice